Mounjaro, Wegovy and Ozempic: Why Strength Training Matters When You’re Losing Weight

What are GLP-1s like Ozempic?

Ozempic (semaglutide) and other GLP-1s have become one of the most discussed medications in the world of weight loss. Originally developed to treat Type 2 diabetes, it has gained widespread attention for its ability to suppress your appetite and support significant weight loss. But from a personal trainer’s standpoint, particularly when it comes to strength training, it’s important to understand not only the positive side, but also the challenges Ozempic and other GLP-1s present.

Ozempic, and similar drugs for fat loss, don’t come without serious issues you need to consider

What Are The Benefits of Ozempic in Combination with Strength Training?

For people struggling with losing weight in traditional ways, for whatever reason, there are some significant benefits to this new suite of drugs.

Appetite Control that Supports Caloric Deficits

Ozempic reduces hunger by acting on the brain’s appetite centers. This helps you maintain a calorie deficit more easily, which is essential for weight loss. Basically, you’re not going to feel very hungry. When combined with a structured strength training program, the resulting calorie deficit can lead to fat loss while strength training works to preserve lean muscle mass.

Easier Physical Activity and Mobility

As clients who are very overweight lose weight with Ozempic, physical movement often becomes easier and more comfortable. Reduced joint stress and improved mobility allow clients to participate more fully in strength training programs that may have previously felt out of reach or just too damn hard.

Medically Supervised Weight Loss

Because Ozempic is prescribed and monitored by healthcare professionals, there is a layer of safety not found in unregulated supplements – of which gym-world is rife (and yes, steroids exist to drop body fat as well as increase muscle mass!). Whilst we would argue that the long term effects (both psychological and physical) are far from fully calculated, at least getting this through your doctor means you’ll have access to blood work and proper evaluation, rather than Big Dave from round the back of the gym telling you “it’s all legit gear, mate”.

Psychological Boost

Seeing the scale move is highly motivating for clients who have struggled with weight loss. This can encourage greater engagement with strength training and other forms of exercise, creating a positive feedback loop – and meaning that you might start seeing exercise as a bigger and bigger part of the solution, rather than punishment.

The Downsides of Ozempic for Strength Training Clients

So, it’s pretty clear that there’s a decent upside to introducing a pretty powerful new drug into your body. But, like everything, there’s downsides.

Risk of Muscle Loss Without Proper Training

Rapid weight loss, especially without adequate strength training and protein intake, results in the loss of muscle mass. Lean muscle is critical not only for strength and aesthetics but also for metabolic health. Clients on Ozempic must engage in consistent strength training to preserve muscle tissue. It is SO hard to gain lean muscle tissue – especially if your older or female – that losing it shouldn’t really be considered an option. Strength training while taking Ozempic will minimise muscle loss.

You’re Unlikely To Develop Good Habit Formation

While Ozempic can make it easier to eat less, it doesn’t automatically teach you how to make sustainable food choices or build long-term healthy habits. Strength training requires consistency, discipline, and nutritional education — all of which remain essential for ongoing success after stopping the medication. Unfortunately, no-one has yet found a pill that takes care of this side of your health.

The Side Effects Have An Impact On Training

Common side effects such as nausea, digestive issues, and fatigue can make it difficult for some clients to train consistently. At RWF, we’re aware of these potential setbacks and can adjust our programming to get you through it.

It’s definitely worth taking a very good probiotic supplement whilst using Ozempic – this is a decent one we often recommend

It’s Not Cheap!

GLP-1s can be costly and the cost isn’t always covered for weight loss alone. If you start, and are forced to stop the medication due to cost, you may experience weight regain if you haven’t developed supportive lifestyle habits alongside their strength training regimen. That’s a massive part of RWF’s training approach with all clients – teaching you what works in the long term, drugs or no drugs.

Risk of Dependence on Medication

Some clients may view Ozempic as the primary reason for their progress and overlook the critical role of strength training, nutrition, and behavioural change. That can lead to addiction. We’ll make sure you get the credit for YOUR role in your weight loss over and above the chemical effect.

RWF’s Verdict: GLP-1s and Strength Training Work Best Together

GLP-1s can serve as a valuable tool for weight loss, but when paired with a well-structured strength training program you’re going to see more of the results you imagine, than just the drug alone.

Strength training not only preserves muscle mass during weight loss but also supports long-term metabolic health, function, and overall body composition. In short, you’re going to look a hell of a lot better, move better and be stronger if you strength train in tandem.

For clients considering Ozempic or other GLP-1s, we very strongly recommend:

• Progressive strength training 2-4 times per week. Our personal training will help.
• Adequate protein intake to support muscle retention; without this, your weight loss will take valuable muscle with it. RWF recommend a good protein supplement like this to help.
• Nutritional education to foster long-term healthy eating habits, unless you want to be Ozempic for the rest of your life
• Habit coaching to build resilience beyond medication use

Don’t just take our word for it. The UK’s Chief Medical Officer’s updated their guidance around GLP-1s in June 2026 to specifically mention undertaking strength training to preserve muscle.

This medication may help initiate weight loss, but it is strength training and sustainable lifestyle changes that will keep the weight off and prevent the all-too-common yo-yo dieting effect. There’s a very real danger that without addressing habits and lifestyle, you’ll not only put the weight back on – you’ll likely put MORE back on.

If you’re starting something like Ozempic or already using it, and want professional guidance on how to protect muscle, build strength, and achieve lasting health improvements, reach out to us at Real World Fitness Nottingham. We specialise in coaching clients through with real-world, sustainable solutions – we don’t offer quick fixes. We want you to win long-term.

FAQs

1. Will Ozempic make me lose muscle if I’m lifting?
   Not if you strength train consistently and get enough protein. The risk rises with rapid weight loss plus low protein and no resistance work.

2. How much protein should I aim for when using GLP-1s?
   A simple rule:  around 1.6–2.2 g per kg body weight daily, spread across meals. Shakes can help if your appetite is low.

3. How often should I train?
   2–4 strength sessions per week, with progressive loads, focusing on big compound lifts plus accessory work for weak points.

4. What if nausea or fatigue hits?
   Adjust your volume and intensity, use more machine work, shorten your sessions, and just keep the habit going. Consistency beats intensity.

5. Can I just do cardio while on Ozempic?
   Cardio helps health and calorie burn, but lifting is what protects muscle and shape during weight loss. So yes, you can, but you’re unlikely to be happy with the end aesthetic results.

If you’re in Colwick, Netherfield, West Bridgford, or anywhere else in Nottingham and you’re considering personal training, now’s your chance!

Book your FREE personal training session today and see how working with dedicated professionals can speed up your fitness journey.